I define a "situation" as an offensive action that engages two or more defenders simultaneously. For example, most screening actions create situations, an attacking drive generates a situation, and many times just feeding a competent post player instigates a situation.
If your opponent lacks cohesion as a defensive unit, a single situation may be enough to break them open for a score. The reality, though, is that most defensive teams are better coached and more prepared: they are capable of helping and recovering as well as double-teaming and rotating back without giving up a scoring opportunity.
But, just because a team can handle one situation doesn't mean they can handle two or three in a row, or even two or three simultaneously.
Set this as a goal for your Read & React team (especially when you come up against better defensive teams): every possession, force the defense to handle more than one situation back to back or at the same time.
Below are a couple of examples of how you can do that.